Effect of mometasone furoate/formoterol combination therapy on nocturnal awakenings in subjects with persistent asthma
نویسندگان
چکیده
Methods Subjects were asthmatics previously using low(n=746), medium(n=781) or high-dose (n=728) inhaled corticosteroids ICS. Low-dose subjects were randomized to 26-wk treatment with MF/F 100/10μg, MF 100μg, F 10μg, or placebo; medium-dose subjects to 26-wk treatment with MF/F 200/10μg, MF 200μg, F 10μg, or placebo; high-dose subjects to 12-wk treatment with MF/F 400/10μg, MF/F 200/10μg, or MF 400μg. All treatments were delivered twice-daily via metered-dose inhaler.
منابع مشابه
190 Effect of Mometasone Furoate/Formoterol Combination Therapy on Nocturnal Awakenings in Subjects With Persistent Asthma
AUC0–12h values with MF/F 200/10 mg, MF/F 400/10 mg, and MF 400 mg correspond to average hourly increases of 0.30, 0.35, and 0.17 L, respectively. MF/F was associated with a rapid (,5 minutes) and sustained improvement in lung function. The percentages of subjects experiencing an asthma deterioration (ie, severe asthma exacerbation) were 12.4% (MF/F 200/10 mg), 12.2% (MF/F 400/10 mg), and 18.3%...
متن کاملEfficacy and safety of combined medium-dose mometasone furoate/formoterol (MF/F) in persistent asthmatics
Background The availability of controller therapies at multiple strengths is important to treat different severities of asthma (NHLBI and GINA guidelines). The clinical effect of medium-dose mometasone furoate/formoterol (MF/F) combination administered via single inhaler had never been characterized in asthmatic subjects versus placebo. We investigated the effect of medium-dose MF/F administere...
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Methods All studies enrolled subjects (≥12y) with persistent asthma not well controlled on inhaled corticosteroids (ICS): study 1 (n=746 subjects with moderate persistent asthma randomized to 26wk MF/F-100/10μg, MF-100μg, F-10μg, or placebo twice daily [BID]); study 2 (n=781 subjects with moderate persistent asthma randomized to 26wk MF/F-200/10μg, MF-200μg, F-10μg, or placebo BID); study 3 (n=...
متن کاملEfficacy and safety of medium and high doses of mometasone furoate/formoterol (MF/F) combination treatment in subjects with severe persistent asthma
Materials and methods This was a 3-month, randomized, double-blind, parallelgroup, multicenter study with a 2-3-week open-label, run-in period of mometasone furoate (MF) 400 μg twice-daily (BID). Subjects (≥12 years) were randomized to MF/F (200/10 μg or 400/10 μg BID) or MF (400 μg BID). The primary endpoint was the area under the curve (AUC) of the change in serial FEV1 (0-12 hours) for MF/F ...
متن کامل191 Quality of Life Improvements in Persistent Asthma Subjects Receiving Combined Mometasone Furoate and Formoterol
AUC0–12h values with MF/F 200/10 mg, MF/F 400/10 mg, and MF 400 mg correspond to average hourly increases of 0.30, 0.35, and 0.17 L, respectively. MF/F was associated with a rapid (,5 minutes) and sustained improvement in lung function. The percentages of subjects experiencing an asthma deterioration (ie, severe asthma exacerbation) were 12.4% (MF/F 200/10 mg), 12.2% (MF/F 400/10 mg), and 18.3%...
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